Hello,good afternoon to all of you.

Well,maybe good evening for the colleagues in Asia and good morning for colleagues in

other countries like the US,America.

So it's for me a great pleasure and an honor to introduce today the speaker,Alfio Quateroni.

He's someone that we all know.

Actually,I would say probably Alfio is one of the main reference models of scientists,influential

scientists in our broad field of applied mathematics for the maybe the last 40 years or so.

Actually I have the chance of meeting Alfio for the first time.

I was doing my master in Paris 6 and then he came by visiting.

He was a bit more senior than I by the time.

So he was probably a junior professor.

At that time he was visiting the laboratory because he was working with Claudio Canuto

and Yvonne Made on spectral methods at that time.

Since then,maybe 35,40 years his trajectories are spectacular.

He has done so many things.

So we have seen Alfio,his books,right?

So his books that we all use at all levels,teaching,research and also to get,you know,to get trained

into new topics.

We identify Alfio also for the last 20 years at least with mocks in Milano where he is

now and also with the chair in EPFL where he has developed an amazing activity training

young people getting into new topics.

He has always been a pioneer,right?

And today he is lecturing on the simulation of the health function.

This is a topic in which he has been working maybe for the last 15 years or so.

I remember he was a plenary speaker in the International Congress of Mathematicians back

in 2006 in Madrid,right?

And by then he was already developing great new applied math in this impactful area.

And then from the Mathematics of Data Center here at FAO in Erlangen where we try to gather

a broad community of applied and mathematicians and data scientists,we thought that definitely

this lecture,this topic and especially this speaker Alfio will have been,will be one of

the best possible choices.

So Alfio could not do it in person today here,but he was kind enough to accept to deliver this

talk online.

And well,in this online age,I think this is actually a very good solution because in this

way his lecture will not only get to the colleagues here in Erlangen,but to a much broader audience

worldwide.

Anyhow,we expect to have Alfio soon in person here,maybe next Academy year.

And so Alfio,gracias.

So Alfio is a model for all of us,also a great friend.

So we are really delighted.

So Alfio,please go ahead.

Thank you very much,Erik,for this very kind words.

I'm very happy to be here.

Sorry,not being able to make it in person.

Well,this is as Erik was saying,this is a topic,is not the only topic I'm working on,but

it's certainly the most important one for me for the past 20 years or so.

So we started about 20 years ago with trying to solve the problems in what we can call

computational medicine and always with the idea of being helpful to doctors.

So starting from real problems.

And more recently,say in the past 10 years,we decided to go into the difficult task of modeling