With this module, participating students should increase and consolidate their knowledge and understanding of medical physics in the field of Nuclear Medicine. For this, all necessary physical foundations and principles will be taught in order that the students are able to explain, interpret, and apply these (for example calculations for the interaction of photons and electrons with matter). With these foundations, the students compare different types of detectors for spatially-resolved photon detection, formulate the principles of imaging in nuclear medicine, and transfer this knowledge to 3-dimensional emission computed tomography. The students differentiate Positron Emission Tomography (PET) and Single-Photon Emission Computed Tomography (SPECT) and understand the principle of 3-D image reconstruction from projection data. They acquire differentiating criteria and quality metrics for image data and use them for assessing reconstruction- and correction methods of PET and SPECT. The students use their acquired knowledge of emission tomography and other imaging modalities such as CT and MRI in order to explain the function principle of multimodal devices such as SPECT/CT, PET/CT, and PET/MRI and in order to evaluate their pros and cons. The students differentiate the relevant application fields of Nuclear Medicine imaging, which are therapeutic, diagnostic and pre-clinical research and interpret the according image data. Based on the acquired competences and with methods obtained from literature review, the students develop solutions for image based dosimetry in Nuclear Medicine therapies and calculate radiation organ doses for representative data. The students translate theory, principle, and rationale of quality assurance of imaging devices to practice and explain the underlying effects. With help of rules and standards, the students understand principles and core of radiation protection and apply these to the field of Nuclear Medicine.